Comparative genomic hybridization (CGH) was used to identify recurrent regions of DNA sequence loss and gain in 21 multiple myeloma (MM) and plasma cell leukemia (PCL) primary tumor specimens and cell lines. Multiple regions of non-random sequence loss and gain were observed in 8/8 primary advanced
✦ LIBER ✦
Cytogenetic abnormalities in acute leukemia complicating melphalan-treated multiple myeloma
✍ Scribed by Stig Rödjer; Birgitta Swolin; Aleksander Weinfeld; Jan Westin
- Book ID
- 119104736
- Publisher
- Elsevier Science
- Year
- 1990
- Tongue
- English
- Weight
- 384 KB
- Volume
- 48
- Category
- Article
- ISSN
- 0165-4608
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## Abstract ## BACKGROUND: Myeloma survival varies markedly with International Staging System classification, presence of cytogenetic abnormalities, and, especially, gene expression profiling‐based risk and delTP53 status, whose collective impact has not been examined in the context of specific th