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Cytodiagnosis of well differentiated hepatocellular carcinoma

✍ Scribed by de Boer, W Bastiaan ;Segal, Amanda ;Frost, Felicity A ;Sterrett, Gregory F

Publisher: John Wiley and Sons
Year: 1999
Tongue: English
Weight: 436 KB
Volume: 87
Category: Article
ISSN: 0008-543X
DOI: 10.1002/(sici)1097-0142(19991025)87:5<270::aid-cncr6>3.0.co;2-l

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✦ Synopsis

BACKGROUND. Distinction of well differentiated hepatocellular carcinoma (HCC)

from benign hepatocellular lesions is a well recognized problem in fine-needle aspiration (FNA) cytology, sometimes leading to indeterminate reports. The aim of this study was to critically examine criteria that might allow definitive diagnosis in these cases.

METHODS.

FNA smears and cell blocks from 65 patients with primary hepatocellular lesions were reviewed. Seventy separate samples had been obtained. The initial reports in these samples were: HCC in 34, benign findings in 27, and indeterminate findings in 9. We defined architectural and cytological features seen in the malignant cases but not seen in the benign cases, including an assessment of reticulin in cell blocks. These criteria were then applied to the indeterminate cases.

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