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Cytochrome P450 oxygenases of Taxol biosynthesis

✍ Scribed by Rüdiger Kaspera; Rodney Croteau

Publisher
Springer
Year
2006
Tongue
English
Weight
282 KB
Volume
5
Category
Article
ISSN
1568-7767

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Coexpression in yeast of Taxus cytochrom
Coexpression in yeast of Taxus cytochrome P450 reductase with cytochrome P450 oxygenases involved in Taxol biosynthesis
✍ Stefan Jennewein; Hangil Park; JingHong M. DeJong; Robert M. Long; Arthur P. Bol 📂 Article 📅 2005 🏛 John Wiley and Sons 🌐 English ⚖ 545 KB

## Abstract To maximize redox coupling efficiency with recombinant cytochrome P450 hydroxylases from yew (__Taxus__) species installed in yeast for the production of the anticancer drug Taxol, a cDNA encoding NADPH:cytochrome P450 reductase from __T. cuspidata__ was isolated. This single‐copy gene