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Cytochrome P450 maintenance and diazepam metabolism in cultured rat hepatocytes

✍ Scribed by Evelynn A. Blankson; Richard J. Chenery; Alan J. Paine


Book ID
115782158
Publisher
Elsevier Science
Year
1991
Tongue
English
Weight
652 KB
Volume
42
Category
Article
ISSN
0006-2952

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The cytochrome P-450 content promptly fell in adult rat hepatocytes cultured in conventional conditions whereas no obvious change was detected over a 10-day period when these cells were co-cultured with another rat liver epithelial cell type. A concomitant maintenance of the amino-pyrine N-demethyla