Clinical implications of dose-dependent
Clinical implications of dose-dependent cytochrome P-450 drug–drug interactions with antidepressants
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C. L. DeVane
📂
Article
📅
1998
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John Wiley and Sons
🌐
English
⚖ 123 KB
The magnitude of drug±drug interactions in vitro involving competitive inhibition of cytochrome (CYP) isozymes by newer antidepressants can theoretically be shown to be dependent upon several factors. These include the concentration of both the substrate and inhibitor, the anity of the inhibitor for