Abstract
This study investigated the association between polymorphisms in cytochrome P450 genes (__CYP1A1__MspI, __CYP1A1__HincII, and __CYP__2E1) and low birth weight. Between July 1999 and June 2002, we conducted a study using infantβparents triads in Anqing, China. The analyses included the families of 248 normal birth weight, fullβterm infants, and 248 lowβbirthβweight infants. Genotyping was performed for the polymorphisms of cytochrome P450 genes using standard techniques. We used logβlinear modeling to analyze the association of CYP1A1 and __CYP__2E1 gene polymorphisms with the risk of low birth weight. In the analysis of children's genotypes, the relative risk was 1.92 (95% confidence interval: 1.05, 3.52, p=0.034) for __CYP1A1__MspI C/C6235 compared with CYP1A1 MspI T/T6235. In the analysis of mothers' genotypes, an association was also seen for maternal __CYP1A1__MspI C/C6235 compared with __CYP1A1__MspI T/T6235 (relative risk: 1.68, 95% confidence interval: 1.06, 2.68, p=0.029). We did not observe a joint effect between mother's and children's genotypes. Analysis of control triads suggests Mendelian transmissions of the variant alleles of __CYP1A1__MspI, __CYP1A1__HincII, and __CYP__2E1. In conclusion, both infant and maternal __CYP1A1__MspI C/C6235 genotypes were associated with increased risk of low birth weight in our study population. This suggests a possible role for human cytochrome P450 variability in the etiology of low birth weight. Genet. Epidemiol. 2005. Β© 2005 WileyβLiss, Inc.