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Cytochrome P450 expression in human keratinocytes: an aryl hydrocarbon receptor perspective

✍ Scribed by Hollie I. Swanson


Book ID
113517072
Publisher
Elsevier Science
Year
2004
Tongue
English
Weight
286 KB
Volume
149
Category
Article
ISSN
0009-2797

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The immortalized human epithelial cell line MCF10A has the phenotypic characteristics of normal breast cells. Exposure of MCF10A cultures to 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) stimulated the transcriptional activation of cytochrome P450 1A1 (CYP1A1), and CYP1B1, and NAD(P)H:quinone oxidoredu