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Cytochrome P450 enzyme-mediated degradation of Echinacea alkylamides in human liver microsomes

✍ Scribed by A. Matthias; E.M.J. Gillam; K.G. Penman; N.J. Matovic; K.M. Bone; J.J. De Voss; R.P. Lehmann

Book ID
113517171
Publisher
Elsevier Science
Year
2005
Tongue
English
Weight
208 KB
Volume
155
Category
Article
ISSN
0009-2797

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Enzymatic denitrification of 2-nitropropane (2NP) was investigated in an NADPH-dependent hepatic microsomal system from male CD1 mice. The involvement of cytochrome P-450 (P-450) as the catalyst in 2NP denitrification was revealed by the induction of nitrite-releasing activity following phenobarbita