Cytochrome P450 1B1 mRNA levels in peripheral blood cells and exposure to polycyclic aromatic hydrocarbons in Chinese coke oven workers
β Scribed by Tomoyuki Hanaoka; Yuko Yamano; Guowei Pan; Kunio Hara; Masayoshi Ichiba; Jiusong Zhang; Shujuan Zhang; Tiefu Liu; Landi Li; Ken Takahashi; Jun Kagawa; Shoichiro Tsugane
- Book ID
- 114097434
- Publisher
- Elsevier Science
- Year
- 2002
- Tongue
- English
- Weight
- 121 KB
- Volume
- 296
- Category
- Article
- ISSN
- 0048-9697
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π SIMILAR VOLUMES
## Background: We investigated if blood cu++/zn++ superoxide dismutase, glutathione peroxidase, and catalase activities are increased and total plasma antioxidant concentration is decreased in coke oven workers exposed to polycyclic aromatic hydrocarbons. ## Methods: Ninety-six coke oven workers
## Abstract Carcinogenic polycyclic aromatic hydrocarbons(a) form DNA adducts via a complex metabolic activation pathway that includes cytochrome P450(a) 1A1, whereas intermediate metabolites can be detoxified by conjugation through pathways including glutathione sβtransferase M1 (GSTM1). PAHβDNA a