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Cytochrome P-450 mRNA Expression in Human Liver and Its Relationship with Enzyme Activity

✍ Scribed by Cristina Rodrı́guez-Antona; M.Teresa Donato; Eugenia Pareja; Maria-José Gómez-Lechón; José V. Castell

Book ID
115568895
Publisher
Elsevier Science
Year
2001
Tongue
English
Weight
110 KB
Volume
393
Category
Article
ISSN
0003-9861

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## Abstract Cytochrome P450 (CYP) substrates that yield fluorescent metabolites were used for rapid screening of drug metabolism activities of 13 recombinant human cytochromes P450, human liver microsomes and human hepatocytes. Reproducible results were obtained using a fluorescent plate reader (Cy