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Cytochrome P-450 “alcohol” in the liver of alcoholics

✍ Scribed by Tong, A.K.W.; Kennedy, B.W.; Moxley, J.E.


Book ID
122485702
Publisher
Elsevier Science
Year
1988
Tongue
English
Weight
73 KB
Volume
7
Category
Article
ISSN
0168-8278

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Alcohol-inducible cytochrome P-450 (P-45
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Of the family of P-450 cytochromes occurring in rabbit liver microsomes, only isozyme 3a (P-450ALC) is induced by alcohol administration and is effective in catalyzing the reaction: ethanol +02+NADPH+H+----acetaldehyde +2H2O+NADP+. As judged by immunochemical quantitation, P-450ALC is also induced i