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Cytochrome c Is Dispensable for Fas-Induced Caspase Activation and Apoptosis

✍ Scribed by Juliane Vier; Georg Linsinger; Georg Häcker

Book ID: 115584047
Publisher: Elsevier Science
Year: 1999
Tongue: English
Weight: 85 KB
Volume: 261
Category: Article
ISSN: 0006-291X
DOI: 10.1006/bbrc.1999.0942

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## Abstract XIAP is an important antiapoptotic protein capable of conferring resistance to cancer cells. Embelin, the small molecular inhibitor of XIAP, possesses wide spectrum of biological activities with strong inhibition of nuclear factor kappa B and downstream antiapoptotic genes. However, the