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Cystothiazoles C-F, new bithiazole-type antibiotics from the myxobacterium Cystobacter fuscus

✍ Scribed by Yoshihiro Suzuki; Makoto Ojika; Youji Sakagami; Ryosuke Fudou; Shigeru Yamanaka

Book ID: 104208826
Publisher: Elsevier Science
Year: 1998
Tongue: French
Weight: 372 KB
Volume: 54
Category: Article
ISSN: 0040-4020
DOI: 10.1016/s0040-4020(98)00694-2

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✦ Synopsis

Bithiazole-type antifungal products, cystothiazoles C-F (3-6), have been isolated from a culture broth of the myxobacterium Cystobacterfuscus as minor components. These are structurally related to cystothiazole A (1), which was isolated as a cytotoxic antibiotic from the same microorganism in our previous work. The structures of these compounds were elucidated by spectroscopic analyses.

These new compounds inhibit the phytopathogenic fungus, Phytophthora capsici, but are less active than 1.

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