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Cystic lymph node metastasis in patients with head and neck cancer: An HPV-associated phenomenon

✍ Scribed by David Goldenberg; Shahnaz Begum; William H. Westra; Zubair Khan; James Sciubba; Sara I. Pai; Joseph A. Califano; Ralph P. Tufano; Wayne M. Koch

Publisher: John Wiley and Sons
Year: 2008
Tongue: English
Weight: 122 KB
Volume: 30
Category: Article
ISSN: 1043-3074
DOI: 10.1002/hed.20796

No coin nor oath required. For personal study only.

✦ Synopsis

Abstract

Background.

Cystic lymph node metastases have been associated with tonsil cancer. A subset of oropharyngeal cancers contain human papillomavirus (HPV) DNA. The clinical and virologic associations of cystic nodal metastasis in head and neck cancer (HNSCC) were investigated.

Methods.

A retrospective review of patients undergoing neck dissection between 2002 and 2004 identified patients with cystic lymph node metastases. Clinical and pathologic information was recorded. The presence of HPV DNA was analyzed using in situ hybridization in a subset of patients.

Results.

One hundred neck dissections were reviewed and 20 had cystic nodes. Seventeen of these patients had primary tumors arising in the palatine or lingual tonsil. Three were “unknown primary.” HPV DNA was present in 11 of 13 patients with cystic metastases with tissue available for analysis (87%). No HPV DNA was identified in tumor from 21 patients with solid nodal metastasis (p <.0001).

Conclusion.

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