๐”– Bobbio Scriptorium
โœฆ   LIBER   โœฆ

Cystic fibrosis: Normal volumes of red cells

โœ Scribed by H. M. Emrich; J. Heitz; S. Katz; R. Thom

Publisher
Springer
Year
1976
Tongue
English
Weight
202 KB
Volume
122
Category
Article
ISSN
0340-6997

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โœฆ Synopsis

Normal values of mean cell volume (M.C.V.) and of distribution of single cell volumes (S.C.V.) have been observed in erythrocytes of patients with cystic fibrosis using an electronical particle-volume analyzer (sheath flow detector). From these results a strong defect in red cell salt transport seems improbable. Valinomucin induces shrinking (by increase of K+ permeability) and gramicidin D induces swelling (by increase of Na+ permeability) of normal erythrocytes. Addition of C.F. sweat to normal erythrocytes induces no volume change. From this result no influence of the "C.F. factor" on passive ion permeability is concluded.

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