Cystic dilatation of peribiliary glands in livers with adult polycystic disease and livers with solitary nonparasitic cysts: An autopsy study
✍ Scribed by Tetsuji Kida; Yasuni Nakanuma; Tadashi Terada
- Publisher
- John Wiley and Sons
- Year
- 1992
- Tongue
- English
- Weight
- 736 KB
- Volume
- 16
- Category
- Article
- ISSN
- 0270-9139
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✦ Synopsis
Cystic dilatation of peribiliary glands of intrahepatic and extrahepatic bile ducts was investigated in autopsied livers with adult polycystic disease (n = 81, in autopsied livers with solitary nonparasitic cysts (n = 18) and in normal autopsied livers (n = 23). In normal livers, cystic dilatation of intrahepatic peribiliary glands was absent or slight, when present. In livers with solitary nonparasitic cysts, cystic dilatation of intrahepatic peribiliary glands was present in varying degrees. In livers with adult polycystic disease, intrahepatic peribiliary glands showed frequent and severe cystic dilatation so marked that it was grossly recognizable. In contrast, peribiliary glands of the extrahepatic bile ducts showed no cystic dilatation in most cases, regardless of the three conditions examined. Liver parenchymal cysts were numerous in livers with adult polycystic disease, few in livers with solitary nonparasitic cysts and nonexistent in normal livers. Von Meyenburg complexes were present in 87.6% of livers with adult polycystic disease, in 16.7% of livers with solitary nonparasitic cysts and in 4.3% of normal livers. These findings suggest that intrahepatic peribiliary glands undergo cystic dilatation in livers with adult polycystic disease-and, to a lesser degree and frequency in livers with solitary nonparasitic cysts, probably because of congenital or genetic factors-and that these cystic changes may comprise a part of numerous cysts of adult polycystic disease. (HEPATOLOGY 1992;16334-340.).
It is well known that the human extrahepatic bile duct harbors glandular elements (extrahepatic peribiliary glands) (1, 2). Our previous studies have disclosed that such glandular elements are also present around the human intrahepatic large bile ducts (intrahepatic peribiliary glands) (3, 4). We have investigated the anatomy and pathological appearance of the intrahepatic peribiliary glands and reported several pathological features such as heterotopic pancreas, hyperplasia, necroinflammation and carcinomatous transformation (5-13).