Vascular smooth muscle cells can reversibly change from a differentiated, contractile to a de-differentiated, synthetic phenotype; de-differentiation correlates with decreased expression of smooth muscle (SM)-specific genes and loss of cGMP-dependent protein kinase (PKG), and transfection of PKG int
β¦ LIBER β¦
Cysteine-rich protein 2 is a downstream effector of cGMP-dependent protein kinase I in nociception
β Scribed by Achim Schmidtko; Wei Gao; Matthias Sausbier; Inga Grundei; Ellen Niederberger; Klaus Scholich; Andrea Huber; Hans-Dieter Allescher; Franz Hofmann; Peter Ruth; Gerd Geisslinger
- Publisher
- BioMed Central
- Year
- 2007
- Tongue
- English
- Weight
- 182 KB
- Volume
- 7
- Category
- Article
- ISSN
- 1471-2210
No coin nor oath required. For personal study only.
β¦ Synopsis
Our studies were supported by the Deutsche Forschungsgemeinschaft [SFB 553 (C6)].
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## Abstract The biochemical differences among cGMP phosphodiesterases in platelets have not been thoroughly examined, primarily due to the lack of sufficient purified material. This report describes a simple method developed to isolate specific bovine platelet cGMP phosphodiesterase. This enzyme is