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Cysteine proteases: The S2P2 hydrogen bond is more important for catalysis than is the analogous S1P1 bond

✍ Scribed by B. Asbo´th; Z. Majer; L. Polga´r

Book ID
115920591
Publisher
Elsevier Science
Year
1988
Tongue
English
Weight
237 KB
Volume
233
Category
Article
ISSN
0014-5793

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A number of epoxysuccinyl amino acid benzyl esters (HO-Eps-AA-OBzl, 1) in which the amino acid (AA) had been systematically varied were tested as inhibitors of cathepsins \(\mathrm{L}\) and S. These E-64 analogs were designed to investigate whether selectivity for cathepsin \(\mathbf{L}\) or catheps