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Cysteine protease inhibitors as potential antiparasitic agents

✍ Scribed by Chung, Joon-Yong; Bae, Young-An; Na, Byoung-Kuk; Kong, Yoon

Book ID
120509063
Publisher
Informa plc
Year
2005
Tongue
English
Weight
264 KB
Volume
15
Category
Article
ISSN
1354-3776

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Allicin and derivatives thereof inhibit the CAC1 cysteine proteases falcipain 2, rhodesain, cathepsin B and L in the low micromolar range. The structure-activity relationship revealed that only derivatives with primary carbon atom in vicinity to the thiosulfinate sulfur atom attacked by the active-s