Cystatin C as a marker of cognitive function in elders: Findings from the health ABC study
✍ Scribed by Kristine Yaffe; Karla Lindquist; Michael G. Shlipak; Eleanor Simonsick; Linda Fried; Caterina Rosano; Suzanne Satterfield; Hal Atkinson; B. Gwen Windham; Manjula Kurella-Tamura
- Publisher
- John Wiley and Sons
- Year
- 2008
- Tongue
- English
- Weight
- 114 KB
- Volume
- 63
- Category
- Article
- ISSN
- 0364-5134
No coin nor oath required. For personal study only.
✦ Synopsis
Abstract
We determined whether serum cystatin C, a novel measure of kidney function that colocalizes with brain β‐amyloid, is associated with cognition among 3,030 elders. Those with high cystatin C (n = 445; 15%) had worse baseline scores on Modified Mini‐Mental State Examination or Digit Symbol Substitution Test (p ≤ 0.02) compared with those with intermediate/low level and 7 years greater decline (p ≤ 0.04). Incident cognitive impairment (decline ≥1.0 standard deviation) was greatest among those with high cystatin C (Modified Mini‐Mental State Examination: 38 vs 25%; adjusted odds ratio, 1.92; 95% confidence interval, 1.37–2.69; Digit Symbol Substitution: 38 vs 26%; odds ratio, 1.54; 95% confidence interval, 1.10–2.15). Ann Neurol 2008