𝔖 Bobbio Scriptorium
✦   LIBER   ✦

Cyr61 is up-regulated in prostate cancer and associated with the p53 gene status

✍ Scribed by Hezhe Lv; Ellen Fan; Suozhu Sun; Xiaoxiao Ma; Xiaoyan Zhang; David M.K. Han; Yu-Sheng Cong

Book ID
102305352
Publisher
John Wiley and Sons
Year
2009
Tongue
English
Weight
210 KB
Volume
106
Category
Article
ISSN
0730-2312

No coin nor oath required. For personal study only.

✦ Synopsis

Abstract

Cysteine‐rich 61 (Cyr61) is a member of the CCN protein family that has been implicated in diverse biological processes such as cell adhesion, proliferation, angiogenesis, and tumorigenesis. Altered expression of Cyr61 is found to be associated with human cancers. Here we show that Cyr61 was up‐regulated in prostate cancer cell lines and tumor tissues. A significant correlation of Cyr61 expression was found between benign prostatic hyperplasia and prostate cancer (P = 0.002). However, there was no significant correlation between levels of PSA and Cyr61 expression (P = 0.2). Cyr61 may represent an independent prostate cancer biomarker and potentially a useful therapeutic target for prostate cancer treatment. In addition, our analysis based on published data and data present in this report indicted that levels of Cyr61 expression associated with the status of the tumor suppressor gene p53 in 32 cancer cell lines analyzed, high levels of Cyr61 expression were found in cell lines with mutant or null p53 gene, whereas lower expression levels of Cyr61 in the cell lines with wild‐type p53. We further show that over‐expression of dominant negative p53 or down‐expression of endogenous wild‐type p53 resulted in up‐regulation of Cyr61 expression, suggesting a functional link between Cyr61 and p53 in cancers. J. Cell. Biochem. 106: 738–744, 2009. © 2009 Wiley‐Liss, Inc.

📜 SIMILAR VOLUMES

Amplification of the androgen receptor g
Amplification of the androgen receptor gene is associated with P53 mutation in hormone-refractory recurrent prostate cancer
✍ Koivisto, Pasi A.; Rantala, Immo 📂 Article 📅 1999 🏛 John Wiley and Sons 🌐 English ⚖ 257 KB 👁 2 views

p53 protein expression of 30 hormone-refractory locally recurrent prostate cancers was compared with their matched untreated primary tumour specimens. In addition, androgen receptor (AR) gene amplification and p53 protein immunostaining were compared. p53 positivity increased during hormonal therapy

A polymorphism in the CYP17 gene is asso
A polymorphism in the CYP17 gene is associated with prostate cancer risk
✍ Andrea Gsur; Gabriele Bernhofer; Sonja Hinteregger; Gerald Haidinger; Georg Scha 📂 Article 📅 2000 🏛 John Wiley and Sons 🌐 French ⚖ 63 KB 👁 2 views

CYP17 encodes the enzyme cytochrome P-450c17␣, which mediates both 17␣-hydroxylase and 17,20-lyase in the steroid biosynthesis pathway. A polymorphism in the 5 promoter region of the CYP17 gene has been described. Steroid hormones, especially androgens, are believed to play a key role in the etiolog

Elevated levels of prostate-specific ant
Elevated levels of prostate-specific antigen (PSA) in prostate cancer cells expressing mutant p53 is associated with tumor metastasis
✍ Sean Downing; Clare Bumak; Sheri Nixdorf; Kim Ow; Pamela Russell; Paul Jackson 📂 Article 📅 2003 🏛 John Wiley and Sons 🌐 English ⚖ 468 KB

## Abstract The underlying basis for rising levels of prostate‐specific antigen (PSA) in prostate cancer is not fully understood, but attention has turned to the possibility that loss of normal p53 function might be directly involved. We have investigated the relationship between p53 function and P

Polymorphisms in the CYP1A1 gene are ass
Polymorphisms in the CYP1A1 gene are associated with prostate cancer risk
✍ Bao-li Chang; Siqun L. Zheng; Sarah D. Isaacs; Aubrey Turner; Gregory A. Hawkins 📂 Article 📅 2003 🏛 John Wiley and Sons 🌐 French ⚖ 72 KB 👁 2 views

## Abstract CYP1A1 is likely to play an important role in the etiology of CaP through its function in activating environmental procarcinogens and catalyzing the oxidative metabolites of estrogens. To test the hypothesis that genetic polymorphisms in the __CYP1A1__ gene may be associated with the ri