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CYP3A4 expression to predict treatment response to docetaxel for metastasis and recurrence of primary breast cancer

✍ Scribed by Kenichi Sakurai; Katsuhisa Enomoto; Sadanori Matsuo; Sadao Amano; Motomi Shiono


Book ID
113049517
Publisher
Springer
Year
2011
Tongue
English
Weight
432 KB
Volume
41
Category
Article
ISSN
1436-2813

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## Abstract We studied the relationship between response of breast cancer to docetaxel (DOC) or cylophosphamide + epirubucin (CE) treatment and CYP3A4 mRNA expression in breast tumors. CYP3A4 inactivates DOC but not E, which is a predominant effector in CE treatment. Twenty patients with locally ad