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CYP2E1 genotype and isoniazid-induced hepatotoxicity in patients treated for latent tuberculosis

✍ Scribed by Nicolas Vuilleumier; Michel F. Rossier; Alberto Chiappe; Florence Degoumois; Pierre Dayer; Bernadette Mermillod; Laurent Nicod; Jules Desmeules; Denis Hochstrasser

Publisher: Springer
Year: 2006
Tongue: English
Weight: 143 KB
Volume: 62
Category: Article
ISSN: 0031-6970
DOI: 10.1007/s00228-006-0111-5

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Hepatotoxicity of rifampicin and isoniaz

Hepatotoxicity of rifampicin and isoniazid in children treated for tuberculosis

✍ O. Linna; M. Uhari 📂 Article 📅 1980 🏛 Springer 🌐 English ⚖ 256 KB

In order to determine the hepatotoxicity of rifampicin in children treated for tuberculosis, a survey was performed of 18 children receiving this medicine in combination with isoniazid. Fifteen of the 18 children (83%) showed a rise in ASAT values and 11 (61%) in ALAT values exceeding 39 U/L. Seven