𝔖 Bobbio Scriptorium
✦   LIBER   ✦

CYP2E1-dependent toxicity and up-regulation of antioxidant genes

✍ Scribed by Montserrat Marí; Defeng Wu; Natalia Nieto; Arthur I. Cederbaum


Publisher
BioMed Central
Year
2001
Tongue
English
Weight
982 KB
Volume
8
Category
Article
ISSN
1021-7770

No coin nor oath required. For personal study only.


📜 SIMILAR VOLUMES


Effects of cytochrome P450 (CYP) 2A6 gen
✍ Hiromasa Tsukino; Yoshiki Kuroda; Delai Qiu; Hiroyuki Nakao; Hirohisa Imai; Taka 📂 Article 📅 2002 🏛 John Wiley and Sons 🌐 French ⚖ 67 KB

## Abstract Cytochrome P450 (CYP) 2A6 and __CYP2E1__ are enzymes with a high ability to activate a nitrosamine, 4‐(methylnitrosamino)‐1‐(3‐pyridyl)‐1‐butanone (NNK), to its potent and ultimate carcinogens. The polymorphic __CYP2A6__ and __CYP2E1__ have been implicated in increased susceptibility to

Liver receptor homolog-1 is critical for
✍ Carolien Out; Jurre Hageman; Vincent W. Bloks; Han Gerrits; Maarten D. Sollewijn 📂 Article 📅 2011 🏛 John Wiley and Sons 🌐 English ⚖ 700 KB

Liver receptor homolog-1 (LRH-1) is a nuclear receptor that controls a variety of metabolic pathways. In cultured cells, LRH-1 induces the expression of CYP7A1 and CYP8B1, key enzymes in bile salt synthesis. However, hepatic Cyp7a1 mRNA levels were not reduced upon hepatocyte-specific Lrh-1 deletion