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CYP2A7 polymorphic alleles confound the genotyping of CYP2A6*4A allele

✍ Scribed by Yokoi, T; Fukami, T; Nakajima, M; Sakai, H; McLeod, H L


Book ID
110075467
Publisher
Nature Publishing Group
Year
2006
Tongue
English
Weight
603 KB
Volume
6
Category
Article
ISSN
1470-269X

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The human CYP2A6 enzyme metabolizes certain drugs and pre-carcinogens and appears to be the most important enzyme for nicotine metabolism. At present, more than 10 different allelic variants are known that cause abolished or decreased enzyme activity. Genetic polymorphism in this gene might be of pa