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Cyfra 21-1 in the diagnosis of lung cancer

✍ Scribed by Prisadov, G; Grigorov, L; Utchikov, P; Paskalev, G; Botushanova, ; Tchepileva, K; Utchikov, A

Book ID
118575514
Publisher
Elsevier Science
Year
1998
Tongue
English
Weight
128 KB
Volume
21
Category
Article
ISSN
0169-5002

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## BACKGROUND. Cytokeratins are the intermediate filaments of the cytoskeletal protein located in normal epithelia, tumor, and cultured cells. Recently, a fragment of cytokeratin subunit 19, referred to as CYFRA 21-1, detected in the serum OF patients with nonsmall cell lung cancer, has been repor

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Background. It is known that cytokeratin 19is particularly abundant in carcinoma of the lung. Methods. A sandwich enzyme-linked immunosorbent assay called CYFRA 21-1 was, therefore, developed to detect soluble cytokeratin 19 fragments in serum using two specific monoclonal antibodies (Ks 19.1 and B