Cyclotron production of PET radionuclides: No-carrier-added fluorine-18 with high-energy protons on natural neon gas targets

✍ Scribed by Manuel C. Lagunas-Solar; Omar F. Carvacho

• Publisher: Elsevier Science
• Year: 1995
• Tongue: English
• Weight: 476 KB
• Volume: 46
• Category: Article
• ISSN: 0969-8043
• DOI: 10.1016/0969-8043(95)00148-7

✦ Synopsis

The production of no-carrier-added (NCA) I SF with high-energy protons on natural Ne(Z°Ne 90.51%; 2tNe 0.27%; and 22Ne 9.22%) gas targets was studied with external proton beams in the 68 22 MeV energy range. Single (thin-target) (mCi/t~Ah) yields for the production of tSF were measured. The cumulative (thick-target) yields, and total cross section (mbarn) for Ne(p,x) 18F reactions were also calculated in the 68-22 MeV proton energy region. With 68 MeV H +, a 46 MeV energy thick Ne target exiting at 22 MeV. produces 700-800 mCi/~Ah of ~F at end-of-bombardment (EOB). With 45 22 MeV H + (i.e. 23 MeV energy thick target), the t~F cumulative yields reaches 350 mCi/pAh. These ~F yields are the largest values reported so far. The advantages and the limitations of using H ÷ beams on natural Ne are analyzed together with a discussion on the alternative production of large multi-Curie batches of ~8F for local and regional distribution.