Cyclotron production of no-carrier-added 206Bi (6.24 d) and 205Bi (15.31 d) as tracers for biological studies and for the development of alpha-emitting radiotherapeutic agents
✍ Scribed by M.C. Lagunas-Solar; O.F. Carvacho; L. Nagahara; A. Mishra; N.J. Parks
- Book ID
- 103919829
- Publisher
- Elsevier Science
- Year
- 1987
- Weight
- 855 KB
- Volume
- 38
- Category
- Article
- ISSN
- 0883-2889
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✦ Synopsis
The production and radiochemical purification of no-carrier-added (NCA) bismuth isotopes (i.e. 6.24 d 206Bi and 15.31 d 205Bi) was studied. The Bi isotopes are intended for use as tracers in biodistribution studies and in the design and testing of alpha-emitting radiotherapeutic agents. The total cross sections and yields for the production of 206Bi and 205Bi from the proton bombardment of natural Pb targets were measured using the stacked-foils technique. A radiochemical method for the separation and purification of NCA Bi radioactivities from a multi-gram Pb target was also tested, modified, and improved to provide aqueous solutions of chemically and biologically useful amounts of NCA 206,205Bi for measuring tissue and subcellular-distributions, and for studies covering several chemical aspects of the development of Pb/Bi radiotherapeutic agents.