Cyclotetrapeptide Complexes of Nickel(II) and Palladium(II) by Template Synthesis from Dipeptide Esters with Functionalized Side Chains − Crystal Structure of [(cyclo-Gly-β-Ala-Gly-β-Ala-4H+)Cu](PPN)2
✍ Scribed by Jan Schapp; Katharina Haas; Karlheinz Sünkel; Wolfgang Beck
- Publisher
- John Wiley and Sons
- Year
- 2003
- Tongue
- English
- Weight
- 170 KB
- Volume
- 2003
- Category
- Article
- ISSN
- 1434-1948
No coin nor oath required. For personal study only.
✦ Synopsis
Abstract
The cyclocondensations of dipeptide esters [Gly‐L‐Asp(OMe)~2~, Gly‐L‐Glu(OMe)~2~, L‐AspOMe‐β‐AlaOMe, β‐Ala‐L‐Lys(ψ‐N‐Boc,OMe), β‐Ala‐L‐Orn(ψ‐N‐Boc,OMe)] at nickel(II), palladium(II), and copper(II) templates give dianionic square‐planar complexes of deprotonated cyclotetrapeptides that contain functional groups in the side chains. The complexes with 14‐ or 16‐membered rings were isolated as [Ph~3~PNPPh~3~]^+^ salts. Hydrolysis of {[cyclo‐Gly‐Asp(OMe)‐Gly‐Asp(OMe)‐4H^+^]Pd}^2−^ affords the tetraanionic complex [{cyclo‐Gly‐Asp(O^−^)‐Gly‐Asp(O^−^)‐4H^+^}Pd]^4−^(Li^+^)~2~(PNP^+^)~2~. The crystal structure of (cyclo‐Gly‐β‐Ala‐Gly‐β‐Ala‐4H^+^)Cu~2~ is also reported. (© Wiley‐VCH Verlag GmbH & Co. KGaA, 69451 Weinheim, Germany, 2003)