Cyclosporine metabolic side effects: association with the WNK4 system
β Scribed by Semyon Melnikov; Haim Mayan; Shinichi Uchida; Eliezer J. Holtzman; Zvi Farfel
- Book ID
- 108714177
- Publisher
- John Wiley and Sons
- Year
- 2011
- Tongue
- English
- Weight
- 398 KB
- Volume
- 41
- Category
- Article
- ISSN
- 0014-2972
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π SIMILAR VOLUMES
## Abstract ## Objective To evaluate the contribution of metabolites (methotrexate [MTX] and folate polyglutamate [PG] levels) and pharmacogenetic biomarkers in the folate pathway to the effects of MTX in patients with rheumatoid arthritis not previously treated with this antifolate. ## Methods
Gc-system typing by isoelectric focusing polyacrylamide gel electrophoresis and quantitative assays were carried out on a patient with a karyotype of 46,XY,de1(4)(q12q21.1) and on his parents with normal chromosomes. Although a father-child incompatibility within the Gc-system suggested that its loc