✦ LIBER ✦

Cyclosporine, FK506 and other drugs in organ transplantation

✍ Scribed by Peter J. Morris

Publisher: Elsevier Science
Year: 1991
Tongue: English
Weight: 621 KB
Volume: 3
Category: Article
ISSN: 0952-7915
DOI: 10.1016/0952-7915(91)90107-c

No coin nor oath required. For personal study only.

✦ Synopsis

As experience of the most effective way to use cyclosporine for immunosuppression in organ transplantation grows, new drugs are emerging, which may improve the potency of future immunosuppressive protocols or at least provide alternative drugs in selected situations. These newer agents include FK506, which is undergoing extensive clinical trials, rapamycin, RS-61443 and deoxyspergualin. The increasing understanding of the mechanism of action of some of these drugs on signal transduction pathways in the T cell should allow the development of drugs with perhaps more specific actions.

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