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Cyclosporine and methotrexate: A dangerous combination

โœ Scribed by Korstanje, M.J.; van Breda Vriesman, C.J.P.; van de Staak, W.J.B.M.

Book ID
123023210
Publisher
Elsevier Science
Year
1990
Tongue
English
Weight
415 KB
Volume
23
Category
Article
ISSN
1097-6787

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Louvain (LOU) rats were administered either methotrexate (MTX; 0.3 mg/kg/week or 0.8 mg/kg/week intraperitoneally), cyclosporin A (CSA; 4 mg/kg/day or 10 mg/kg/day continuous infusion via osmotic pump), or a combination of both agents. The rats were immunized with native type I1 collagen (CII) to de