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Cyclosporine A induces endothelin-1 release from cultured rat vascular smooth muscle cells

✍ Scribed by Yoshiyu Takeda; Yuji Itoh; Takashi Yoneda; Isamu Miyamori; Ryoyu Takeda


Book ID
115888245
Publisher
Elsevier Science
Year
1993
Tongue
English
Weight
205 KB
Volume
233
Category
Article
ISSN
0014-2999

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Two important mediators of endothelium-dependent regulation of vascular smooth muscle tone and proliferation are nitric oxide (NO) and endothelin (ET-1). An imbalance between NO and ET-1 may contribute to the alterations in vascular tone characteristic of cardiovascular disease. The objective of thi