Cyclosporin-induced hypertriglyceridemia with prompt response to plasma exchange therapy
✍ Scribed by Dr. M. Valbonesi; D. Occhini; R. Frisoni; L. Malfanti; C. Capra; F. Gualandi
- Publisher
- John Wiley and Sons
- Year
- 1991
- Tongue
- English
- Weight
- 263 KB
- Volume
- 6
- Category
- Article
- ISSN
- 0733-2459
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✦ Synopsis
A case of severe cyclosporin-induced hypertriglyceridemia that prompted plasma exchange therapy is reported. Hyperlipemic retinitis, headache, stupor, and peripheral paresthesias became apparent when the level of triglycerides exceeded the 1,500 mg/dL level. Two plasma exchanges were required to halt disease progression. This is the second time that plasma exchange was used in a bone marrow transplanted patient on cyclosporin-A therapy. In both cases hypertriglyceridemia became apparent and symptomatic after approximately 7 months of therapy with cyclosporin.