Chronic cyclosporin A therapy in rats
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Rajiv Midha; Dr. Susan E. Mackinnon; Judy A. Wade; Peter J. Evans; Timothy J. Be
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Article
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1992
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John Wiley and Sons
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English
β 341 KB
## Abstract We investigated the pharmacokinetics of cyclosporin A (CsA) blood levels and drug toxicity in a chronic rat study in which longβterm (30 weeks) CsA was administered. Ninety Lewis rats received subcutaneous CsA at 5 mg/kg/day for 12 weeks, at which time CsA injections were stopped in 50