Cyclosporin A, FK506 and rapamycin: more than just immunosuppression
โ Scribed by Kunz, Jeannette; Hall, Michael N.
- Book ID
- 120425922
- Publisher
- Elsevier Science
- Year
- 1993
- Tongue
- English
- Weight
- 559 KB
- Volume
- 18
- Category
- Article
- ISSN
- 0968-0004
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Cyclosporin A and FK-506 are important therapeutic agents that have found widespread use in preventing graft rejection during tissue transplantation. Research efforts aimed at elucidating the molecular mechanism of action of these drugs have, in addition to defining their immunosuppressive functions
## Abstract The effects of the immunosuppressants cyclosporin A (CsA), FK506 and rapamycin have been compared using murine B cells activated with a variety of mitogens. FK506 is a macrolide antibiotic that has been recently shown to inhibit T cell activation by a mechanism that appears similar to t