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Cyclosporin A, FK-506, and Rapamycin: Pharmacologic Probes of Lymphocyte Signal Transduction

โœ Scribed by Sigal, N H; Dumont, F J

Book ID
120379281
Publisher
Annual Reviews
Year
1992
Tongue
English
Weight
1020 KB
Volume
10
Category
Article
ISSN
0732-0582

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Suppression of B cell activation by cycl
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โœ Linda S. Wicker; Robert C. Boltz Jr.; Victoria Matt; Elizabeth A. Nichols; Laure ๐Ÿ“‚ Article ๐Ÿ“… 1990 ๐Ÿ› John Wiley and Sons ๐ŸŒ English โš– 722 KB

## Abstract The effects of the immunosuppressants cyclosporin A (CsA), FK506 and rapamycin have been compared using murine B cells activated with a variety of mitogens. FK506 is a macrolide antibiotic that has been recently shown to inhibit T cell activation by a mechanism that appears similar to t