Cyclosporin A Enhances Susceptibility of Multi-drug Resistant Human Cancer Cells to Anti-P-glycoprotein Antibody-dependent Cytotoxicity of Monocytes, but Not of Lymphocytes

Altered expression of P-glycoprotein and

Altered expression of P-glycoprotein and cellular adhesion molecules on human multi-drug-resistant tumor cells does not affect their susceptibility to NK- and LAK-mediated cytotoxicity

✍ Rik J. Scheper; William S. Dalton; Thomas M. Grogan; Arno Schlosser; William T. 📂 Article 📅 1991 🏛 John Wiley and Sons 🌐 French ⚖ 819 KB

Drug resistance has been associated with resistance to NKand LAK-cell-mediated cytotoxicity. We evaluated this issue in human cell lines, using multiple myeloma cells (8226) and 2 multi-drug-resistant (MDR) sublines selected using doxorubicin (8226/Dox40) and mitoxantrone (8226lMR40). In parallel, w