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Cyclosporin A and verapamil have different effects on energy metabolism in multidrug-resistant tumour cells

โœ Scribed by Broxterman, HJ; Pinedo, HM; Schuurhuis, GJ; Lankelma, J


Book ID
109836417
Publisher
Nature Publishing Group
Year
1990
Tongue
English
Weight
707 KB
Volume
62
Category
Article
ISSN
0007-0920

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## Multidrug -resistance (MDR) is characterized by the presence of a 170 kDa glycoprotein (P-glycoprotein) in the plasma membrane. P-glycoprotein is thought to act as an efflux pump, leading to reduced drug accumulation in MDR cells. This defect in drug accumulation can be overcome by membrane tra