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Cyclosporin A and tacrolimus induce renal Erk1/2 pathway via ROS-induced and metalloproteinase-dependent EGF-receptor signaling

✍ Scribed by El-Sayed Akool; Stefan Gauer; Bashier Osman; Anke Doller; Sebastian Schulz; Helmut Geiger; Josef Pfeilschifter; Wolfgang Eberhardt


Book ID
113489683
Publisher
Elsevier Science
Year
2012
Tongue
English
Weight
1004 KB
Volume
83
Category
Article
ISSN
0006-2952

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## Abstract Adenosine, a modulator of neuronal function in the mammalian central nervous system, exerts a neuroprotective effect via the adenosine A~1~ receptor; however, its effect on neural stem cells (NSCs) remains unclear. Because adenosine is released in response to pathological conditions and