Cyclophosphamide-Induced Tolerance in Fully Allogeneic Heart Transplantation in Mice
β Scribed by Akio Matsuura; Masahisa Katsuno; Yoshiko Suzuki; Toshiaki Ito; Kenzo Yasuura; Toshio Abe; Yasunobu Yoshikai
- Book ID
- 112238982
- Publisher
- Elsevier Science
- Year
- 1994
- Tongue
- English
- Weight
- 258 KB
- Volume
- 155
- Category
- Article
- ISSN
- 0008-8749
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## Abstract There are controversial in vitro data comparing the strength of the cellular immune response between allogeneic and xenogeneic stimulator/responder combinations. The present study therefore compares in vivo lymphocyte proliferation using heart transplantation (HTx) models in mice. Heter
## Abstract Specific antibody unresponsiveness was induced in adult CBA/H mice by the injection of cyclophosphamide 24 h after immunization with a large dose of horse red blood cells (HRBC). Four lines of experimental evidence indicated that this unresponsive state was maintained by active T cell r