Cyclophosphamide enhances anti-tumor effect of wild-type p53-specific CTL

The effect of the interferon-γ-inducible

The effect of the interferon-γ-inducible processing machinery on the generation of a naturally tumor-associated human cytotoxic T lymphocyte epitope within a wild-type and mutant p53 sequence context

✍ Ulrike Kuckelkorn; Edite Antunes Ferreira; Ilse Drung; Ulrike Liewer; Peter-Mich 📂 Article 📅 2002 🏛 John Wiley and Sons 🌐 English ⚖ 168 KB 👁 1 views

The human wild-type (wt) p53.264-272 peptide is a universal tumor antigen and recognized by HLA-A\*0201 (A2.1)-restricted CTL. Generation of this epitope by constitutive 20S proteasomes is prevented by a p53 R to H hotspot mutation at the C-terminal flanking residue 273. We report on the impact of t