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Cyclophilin A Modulates Processing of Human Immunodeficiency Virus Type 1 p55Gag: Mechanism for Antiviral Effects of Cyclosporin A

✍ Scribed by Daniel N. Streblow; Moiz Kitabwalla; Miroslav Malkovsky; C.David Pauza


Book ID
112271993
Publisher
Elsevier Science
Year
1998
Tongue
English
Weight
700 KB
Volume
245
Category
Article
ISSN
0042-6822

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A series of human immunodeficiency virus (HIV) mutants was constructed either by deletion or by linker insertion at various regions in the gag coding sequences. The ability of each mutant to assemble virus particles and to process them proteolytically, as well as incorporate cyclophilin A, was analy