Cyclopentanones—III : A new synthesis of (±) allethrolone
✍ Scribed by M. Vandewalle; E. Madeleyn
- Book ID
- 108374011
- Publisher
- Elsevier Science
- Year
- 1970
- Tongue
- French
- Weight
- 303 KB
- Volume
- 26
- Category
- Article
- ISSN
- 0040-4020
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A new method for the stereospecific synthesis of cis-3,4-disubstituted cyclopentanones is described. 4s a part of synthetic studies on biologically active compounds consisting of five membered ring such as prostaglandins, brefeldin A and methylenomycin A, we undertook the stereospecific synthesis of
## Abstract The synthesis of 2,2‐dimethyl‐ and 2,2‐diphenylcyclopentanone in high yield is reported by the ring expansion of the corresponding 1‐(disubstituted carbinol)‐1‐hydroxycyclobutane in polyphosphoric acid. Modifications of the general synthetic route using reported reactions offers a gener
Direct couplings of the cY-bromomethylacrylates and the doubly charged succinate ion are described. For a number of years we have been interested in the development of new annulation which would afford five-membered rings via direct coupling of the fl-haloesters and the doubly charged succinate ions