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Cyclooxygenase (COX) and 5-lipoxygenase (5-LOX) selectivity of COX inhibitors

✍ Scribed by G.F. Sud’ina; M.A. Pushkareva; P. Shephard; T. Klein


Book ID
116838635
Publisher
Elsevier Science
Year
2008
Tongue
English
Weight
406 KB
Volume
78
Category
Article
ISSN
0952-3278

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A series of methysulfonyl or sulfonamido substituted 4,5-diaryloxazole were prepared and evaluated for their ability to inhibit the inducible form of cyclooxygenase (COX-2) in vitro and in vivo. Several unique substitution patterns were identified that led to potent and selective inhibitors of COX-2