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Cyclooxygenase-2 is involved in increased proliferation of neuronal progenitor cells in the ischemic mouse hippocampus

✍ Scribed by Tsutomu Sasaki; Kazuo Kitagawa; Shiro Sugiura; Emi Omura-Matsuoka; Shigeru Tanaka; Yoshiki Yagita; Hideyuki Okano; Masayasu Matsumoto; Masatsugu Hori

Book ID
117551036
Publisher
Elsevier Science
Year
2003
Tongue
English
Weight
68 KB
Volume
1252
Category
Article
ISSN
0531-5131

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Implication of cyclooxygenase-2 on enhan
Implication of cyclooxygenase-2 on enhanced proliferation of neural progenitor cells in the adult mouse hippocampus after ischemia
✍ Tsutomu Sasaki; Kazuo Kitagawa; Shiro Sugiura; Emi Omura-Matsuoka; Shigeru Tanak πŸ“‚ Article πŸ“… 2003 πŸ› John Wiley and Sons 🌐 English βš– 616 KB

## Abstract Global ischemia promotes neurogenesis in the dentate gyrus of the adult mouse hippocampus. Cyclooxygenase (COX)‐2, the principal isoenzyme in the brain, modulates inflammation, glutamate‐mediated cytotoxicity, and synaptic plasticity. We demonstrated that delayed treatment with differen