𝔖 Bobbio Scriptorium
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Cyclooxygenase-2 alters transforming growth factor-β1 response during intestinal tumorigenesis

✍ Scribed by C.A. O'Mahony; R.D. Beauchamp; D. Albo; M. Tsujii; H.M. Sheng; J. Shao; R.N. Dubois; David H. Berger

Book ID
117221333
Publisher
Elsevier Science
Year
1999
Tongue
English
Weight
129 KB
Volume
126
Category
Article
ISSN
0039-6060

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## Abstract ## Background Fibroblasts isolated from strictures in Crohn's disease (CD) exhibit reduced responsiveness to stimulation with transforming growth factor (TGF) β1. TGF-β1, acting through the smad pathway, is critical to fibroblast-mediated intestinal fibrosis. The membrane glycoprotein,