Cyclooctyne-based reagents for uncatalyzed click chemistry: A computational survey

[18F]FPyKYNE, a fluoropyridine-based alk

[18F]FPyKYNE, a fluoropyridine-based alkyne reagent designed for the fluorine-18 labelling of macromolecules using click chemistry

✍ Bertrand Kuhnast; Françoise Hinnen; Bertrand Tavitian; Frédéric Dollé 📂 Article 📅 2008 🏛 John Wiley and Sons 🌐 French ⚖ 183 KB

## Abstract FPyKYNE (2‐fluoro‐3‐pent‐4‐yn‐1‐yloxypyridine) is a novel fluoropyridine‐based structure, designed for the fluorine‐18 labelling of macromolecules using copper‐catalysed Huisgen 1,3‐dipolar cycloaddition (click chemistry). FPyKYNE (non‐labelled as reference), as well as the 2‐bromo, 2‐n