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Cyclohexane analogues of the prostaglandins

✍ Scribed by N.S. Crossley


Publisher
Elsevier Science
Year
1971
Tongue
French
Weight
163 KB
Volume
12
Category
Article
ISSN
0040-4039

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Substituted cyclohexane as conformationa
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A new class of potential leukotriene analogues is synthesized which atttempts to restrict the conformationally mobile lipophilic chain. Biological evaluation shows weak agonist activity, giving key information on LTD4 geometry to the receptor. The peptido-leukotrienes LTC4, LTD., and LTE, are poten