Cyclodextrin mediated solvent-free enantioselective photocyclization of N-alkyl pyridones

✍ Scribed by J Shailaja; S Karthikeyan; V Ramamurthy

• Book ID: 104252485
• Publisher: Elsevier Science
• Year: 2002
• Tongue: French
• Weight: 332 KB
• Volume: 43
• Category: Article
• ISSN: 0040-4039
• DOI: 10.1016/s0040-4039(02)02338-9

✦ Synopsis

Irradiation of N-methyl pyridone and N-ethyl pyridone included in b-cyclodextrin yields the photocylized product, chiral 2-azabicyclo[2.2.0]-hex-5-en-3-ones, in 60% enantiomeric excess. The inclusion complex is readily made by mechanically mixing the host b-cyclodextrin and the guest pyridone.